The 1000th Thread!
Research
|
|||||
case
|
country
|
location
|
year
|
summary
|
|
1880s
|
Psychosurgery (also called neurosurgery for mental disorder)
has a long history. During the 1960s and 1970s, it became the subject of
increasing public concern and debate, culminating in the US with
congressional hearings. Particularly controversial was the work of Harvard
neurosurgeon Vernon Markand psychiatrist Frank Ervin, who wrote a book entitled Violence
and the Brain in 1970.[1] The National Commission for the
Protection of Human Subjects of Biomedical and Behavioral Research in 1977
endorsed the continued limited use of psychosurgical procedures.[1][2]Since then, a few facilities in some
countries have continued to use psychosurgery on small numbers of patients.
In the US and other Western countries, the number of operations has further
declined over the past 30 years, a period during which there have been no
major advances in ablative psychosurgery.[3]
|
||||
United States
|
1920s
|
Controversial psychiatrist Henry Cotton at Trenton State Hospital in New Jersey became
convinced that insanity was
fundamentally a toxic disorder and he surgically removed body parts to try to
improve mental
health.[4]
|
|||
United States
|
Iowa
|
1939
|
The Monster Study is the name given to a stuttering experiment
performed on orphan children in Davenport, Iowa in
1939. It was conducted by Wendell Johnson at
the University
of Iowa. The research began with the selection of 22 subjects from
a veterans' orphanage in Iowa. None were told the intent of the research, and
they believed that they were to receive speech therapy. The study was trying
to induce stuttering in healthy children. The experiment became national news
in the San Jose Mercury News in 2001, and a book
was written. On 17 August 2007, six of the orphan children were awarded
$925,000 by the State of Iowa for lifelong psychological and emotional scars
caused by six months of torment during the Iowa University experiment.
Although none of the children became stutterers, some became self-conscious
and reluctant to speak.[5] A spokesman for the University of Iowa
called the experiment "regrettable".
|
||
United States
|
Various
|
Occurred over many decades
|
There has been a long history of medical experimentation on African Americans.
From the era of slavery, when atrocities were committed on black women
by J.
Marion Sims, to the present day, Black Americans have been
unwitting subjects of medical experimentation.[7][8] Author Harriet Washington argues that
"diverse forms of racial discrimination have shaped both the
relationship between white physicians and black patients and the attitude of
the latter towards modern medicine in general".[9]
In the 1960s, Ionia State Hospital, located in Ionia, Michigan,
was one of America's largest and most notorious state psychiatric hospitalsin the era before
deinstitutionalization. Doctors at this hospital diagnosed African Americanswith schizophrenia because
of their civil
rightsideas. See The Protest Psychosis.
|
||
Plutonium injections
|
United States
|
1945-1947
|
Eighteen people were
injected with plutoniumby Manhattan
Project doctors. None of the patients was told what was going
on, and the doctors did not ask for their consent. See Eileen Welsome's
book The Plutonium Files.[10]
|
||
United States
|
1946
|
German medical
doctors went on criminal trial for Nazi human experimentation. See The Years of Extermination.
|
|||
U.S./
Guatemala |
1946-48
|
The syphilis experiments
in Guatemala were United
States human experiments conducted in Guatemala from
1946 to 1948. The experiments were led by physician John Charles Cutler. They were done during the
administration of American President Harry S. Truman and
Guatemalan President Juan
José Arévalo.[11]
Doctors infected soldiers, prostitutes, prisoners, and mental patients with syphilisand
other sexually transmitted diseaseswithout the informed consent of
the subjects, and treated most subjects with antibiotics. This
resulted in at least 83 deaths.[12] In October 2010, the US formally
apologized to Guatemala for conducting these experiments.
|
|||
United States
|
New York State
|
1950s
|
More than 1200
homeless men from Lower Manhattan were convinced with promises of food and
shelter to have their prostates biopsied by a Dr. Perry Hudson. They were not
informed of possible side effects, i.e., rectal tearing and impotence. The
homeless were targeted for these biopsies because the biopsies were painful
and untested, and less vulnerable populations would not volunteer.
|
||
Radioactive iodine
experiments
|
United States
|
1950s
|
The U.S. Atomic Energy Commission has a history of
involvement in experiments involving radioactive
iodine. In a 1949 operation called the "Green Run,"
the AEC released iodine-131and xenon-133 to
the atmosphere, which contaminated a 500,000-acre (2,000 km2) area containing three small towns near the Hanford site in
Washington.[13] In 1953, the AEC ran several studies
on the health effects of radioactive iodine in newborns and pregnant women at
the University
of Iowa. Also in 1953, the AEC sponsored a study to discover if
radioactive iodine affected premature babies
differently from full-term babies.[14] In another AEC study, researchers at
the University of Nebraska College of Medicine fed
iodine-131 to 28 healthy infants through a gastric tube to test the
concentration of iodine in the infants' thyroid glands.[14]
|
||
United States
|
1951
|
A product derived
from a cancer patient's specimen, HeLa is the cornerstone of an industry.
Cancerous tissue was taken from her without her consent.
|
|||
United States
|
Philadelphia
|
1951-1974
|
Clinical
non-therapeutic medical experiments on prison inmates was
conducted at Holmesburg Prison in Philadelphia from
1951 to 1974 under the direction of dermatologistAlbert Kligman.[15]
|
||
Canada
|
1957–1964
|
The Allan Memorial Institute is known for its role
in the Project
MKULTRA run by the CIA. The Agency's initiative to develop
drug-induced "mind control" techniques was implemented in the
institute by its then-Director Donald Ewen Cameron.
|
|||
UK mental
institutions
|
UK
|
1960s
|
In the 1960s, there
was abuse and inhumane treatment of psychiatric patients who were hidden away
in institutions in the UK. Barbara Robb documented
her difficult personal experience of being treated at Ely Hospital. She
wrote the book Sans Everything and she used this to launch a
campaign to improve or close long stay facilities. Shortly after, a long stay
hospital for the mentally handicapped in Cardiff was exposed by a nurse
writing to the News of the World. This exposure prompted an
official inquiry, which was highly critical of conditions, staff morale, and
management. At the same time Michael
Ignatieff and Peter Townsend both published books which
exposed the poor quality of institutional care.[16]
|
||
United States
|
1961
|
The Milgram
experiment on obedience to authority figures was a series of notable social
psychology experiments conducted
by Yale
University psychologist Stanley Milgram,
which measured the willingness of study participants to obey an authority figure who
instructed them to perform acts that conflicted with their personal conscience.[17] The detailed findings are discussed in
his 1974 book, Obedience to Authority: An Experimental View.[18] The experiments were controversial,
and considered by some scientists to be unethical and physically or
psychologically abusive. Psychologist Diana Baumrind considered
the experiment "harmful because it may cause permanent psychological damage
and cause people to be less trusting in the future." [19]
|
|||
1962-1979
|
Controversial
Australian psychiatrist Harry
Bailey treated mental patients via deep
sleep therapy and other methods at a Sydney mental hospital.
He has been linked with the deaths of 85 patients.[20] He committed suicide before he could
be punished.
|
||||
Soviet Union,
Romania,
Hungary, Czechoslovakia, Yugoslavia and China |
1960s to 1980s
|
Psychiatrists have
been involved in human rights abuses in states across the world when the
definitions of mental disease were expanded to include political
disobedience.[21]:6 In the period from the 1960s to 1986,
abuse of psychiatry for political purposes was reported to be systematic in
the Soviet Union and other Eastern European countries.[22]:66 Political abuse of psychiatry also
takes place in the People's Republic of China.[23] Psychiatric diagnoses such as the
diagnosis of "sluggish schizophrenia" in political
dissidents in the USSR were used for political purposes.[24]:77
|
|||
United States
|
1971
|
The Stanford prison
experiment was a study of the psychological effects
of becoming a prisoner or prison guard. The
experiment was conducted in August 1971 by a team of researchers led by
psychology professor Philip Zimbardo.[25] Participants took on the roles of
prisoners and guards in a mock prison situated
in the basement of the Stanford psychology building. Some of the prisoners
were subjected to psychological torture. Many of the prisoners
passively accepted psychological abuse, and Zimbardo himself permitted the
abuse to continue. Two of the prisoners quit the experiment early and the
entire experiment was abruptly stopped after only six days. Certain portions
of the experiment were filmed and excerpts of footage are publicly available.
|
|||
United States
|
1970s
|
Human radiation
experiments were directed by the United States Atomic Energy Commissionand
the Manhattan Project. In Nashville, pregnant women were given radioactive
mixtures. In Cincinnati, some 200 patients were irradiated over a period of
15 years. In Chicago, 102 people received injections of strontium and cesium
solutions. In Massachusetts, 74 schoolboys were fed oatmeal that contained
radioactive substances. In all of these cases, the subjects did not know what
was going on and did not give informed consent.[10] The government covered up most of
these radiation mishaps until 1993, when President Bill Clinton ordered
a change of policy. The resulting investigation was undertaken by the Advisory Committee on Human
Radiation Experiments. See The Plutonium Files.
|
|||
United States
|
1972
|
A 40-year experiment
conducted by the U.S. Public Health Service withheld standard medical advice
and treatment from a poor minority population with an easily treatable
disease. The experiment targeted black male farmers who were told they needed
to be treated for 'bad blood',[26] some of whom had previously
encountered syphilis. Others were intentionally given syphilis during the
course of the experiment. In addition to many fatalities, some children were
born with congenital syphilis due to the study.
|
|||
United States
|
1976
|
Researchers
commercialized a patient's discarded body parts. The man did not authorize
the use of his bodily tissues or fluids, and researchers did not obtain
informed consent. He did not want his donation to generate commercial profit
for private entities.
|
|||
1980s
|
Eugene Ellsworth
Landy was an American psychologist and psychotherapist best known for his
unconventional 24-hour therapy as well as ethical violations concerning his
treatment of Beach
Boys co-founder Brian Wilson in
the 1980s. In 2015, Landy's relationship with Wilson was dramatized in
the biographical
filmLove & Mercy.
|
||||
United States
|
1987
|
A school had been
infecting disabled children in experiments for years.
|
|||
Canada, United
States
|
12 psychiatric
centers
|
1994–2001
|
SmithKlineBeecham,
known since 2000 as GlaxoSmithKline,
conducted a clinical trial from 1994 to 1997 in 12 pychiatric centers in
North America to study the efficacy of paroxetine(Paxil,
Seroxat), an anti-depressant, on teenagers. The trial data suggested that the
drug was not efficacious and that the paroxetine group were more likely to
think about suicide. The paper that wrote up the study was published in 2001,
osensibly authored by a group of academics, but actually ghostwritten by the
drug company. The article downplayed the negative findings and concluded that
paroxetine helped with teenage depression. The company used this paper to
promote paroxetine for teenagers. The ensuing controversy led to several
lawsuits, including from the parents of teenagers who killed themselves while
taking the drug, and intensified the debate about medical ghostwriting and conflict of interest in clinical trials. In
2012 the US Justice Department fined GlaxoSmithKline $3 billion for several
violations, including withholding data on paroxetine, unlawfully promoting it
for adolescents, and preparing a misleading article about study 329. New
Scientist wrote in 2015: "You may never have heard of it, but
Study 329 changed medicine."[27]
|
||
Death associated
with psychotropic drugs
|
United States
|
1998
|
In 1998,
60-year-old Donald Schell went to see his doctor
complaining of difficulty sleeping. He was diagnosed with an anxiety state
and placed on Paxil, an SSRI anti-depressant. Within 48 hours
of being put on Paxil Schell killed his wife, daughter, infant granddaughter,
and himself. Tim Tobin, Schell’s son-in-law, took legal action against
SmithKline (now GlaxoSmithKline).
The Tobin case was heard in Wyoming from
May 21 to June 6, 2001. The jury returned a guilty verdict against SmithKline
and awarded Tobin $6.4 million.[28][29][30][31]This was the first guilty verdict returned
against a pharmaceutical company
regarding adverse behavioral effects of a psychotropic drug.[28]
|
||
United States
|
2002
|
Courtney is a
former pharmacist who
owned and operated Research Medical Tower Pharmacy in Missouri.[32] In 2002, he was convicted of
pharmaceutical fraud and sentenced to federal prison.[32]
|
|||
United States
|
2003
|
Patients donated
tissue samples, which researchers subsequently used in a plan to generate
profit.
|
|||
GlaxoSmithKlinehuman
experiments
|
Various
|
2004–2012
|
In 2004 GlaxoSmithKline (GSK)
sponsored at least four medical trials using Hispanic and black children
at New
York's Incarnation Children's Center. Normally trials on
children require parental consent but, as the infants were in care, New
York's authorities held that role. Experiments were designed to test the
“safety and tolerance” of AIDS medications,
some of which have potentially dangerous side effects.[33]
In 2006, GSK and the US Army were criticized for Hepatitis E vaccine experiments
conducted in 2003 on 2,000 soldiers of the Royal Nepalese Army. It was said that using
soldiers as volunteers is unethical because they "could easily be
coerced into taking part."[34]
In January 2012, GSK and two scientists who led the trials
were fined approximately $240,000 in Argentina for "experimenting with
human beings" and "falsifying parental authorization" during
vaccine trials on 15,000 children under the age of one. Babies were recruited
from poor families that visited public hospitals for medical treatment.
Fourteen babies allegedly died as a result of the trials.[35]
|
||
Death from
prescription drugs
|
United States
|
2006
|
Rebecca Riley, the
daughter of Michael and Carolyn Riley of Massachusetts, was found dead in her
home at age four, her lungs filled with fluid, after prolonged exposure to
various medications. The medical examiner's office determined the girl died
from "intoxication due to the combined effects" of prescription
drugs. Police reports state she was taking 750 milligrams a day of Depakote, 200
milligrams a day of Seroquel,
and .35 milligrams a day of Clonidine. Rebecca had been taking the drugs
since the age of two for bipolar disorder and ADHD, diagnosed by child psychiatrist Kayoko
Kifuji of the Tufts-New England Medical Center.[36]
|
||
University of MinnesotaResearch Participant Dan
Markingson
|
United States
|
Minnesota
|
2004
|
University of Minnesota research participant Dan Markingson committed
suicide in May 2004 while enrolled in an industry-sponsored pharmaceutical
trial comparing three FDA-approved atypical antipsychotics: Seroquel (quetiapine), Zyprexa (olanzapine),
and Risperdal
(risperidone). Writing on the circumstances surrounding
Markingson's death in the study, which was designed and funded by Seroquel
manufacturer AstraZeneca,
University of Minnesota Professor of Bioethics Carl Elliott noted that Markingson was
enrolled in the study against the wishes of his mother, Mary Weiss, and that
he was forced to choose between enrolling in the study or being involuntarily
committed to a state mental institution.[37] Further investigation revealed financial
ties to AstraZeneca by Markingson's psychiatrist, Dr. Stephen C. Olson,
oversights and biases in AstraZeneca's trial design, and the inadequacy of
university Institutional Review Board (IRB)protections for
research subjects.[38] Although a 2005 FDA investigation
appeared to clear the university, greater awareness of the case stemming from
Elliott's 2010 article in the magazine Mother Jones resulted in a group of
university faculty members sending a public letter to the Board of Regents
urging an external investigation into Markingson's death.[39]
|
case
|
country
|
location
|
year
|
summary
|
|
United States
|
2008
|
A hospital wished to withhold treatment from someone whom it
judges to have no chance of living.
|
|||
United States
|
2008
|
The parents of a brain-dead boy wanted to keep him on life
support.
|
|||
United States
|
2007
|
Prison officials question whether to force-feed inmates who
are on hunger strike.
|
|||
United Kingdom
|
2017
|
After losing a UK Supreme Court case, the parents of Gard, 10
months, petitioned the EU Court in France, and lost the final appeal. They
wanted the hospital to allow them to travel to the U.S. for an experimental
therapy that may have provided some temporary benefit but likely would not have
improved his neurological condition, due to a mitochondrial
DNA depletion disease (the treatment is nucleoside bypass therapy). At the least, they
wanted for the hospital to continue to provide advanced life support palliative care for
their son—respiration, nutrition, hydration—or to send him home on life
support to eventually die, but those requests were also denied and support
will be turned off.
|
|||
United States
|
2005
|
The hospital removes life support from an unconscious immigrant
from Eritrea against
her family's wishes. The family are in a foreign country and unable to
travel.
|
|||
2010
|
A man seems to be in a persistent vegetative state, and after
23 years a communication test is conducted.
|
||||
United States
|
Texas
|
2004
|
An infant is removed from life support against his mother's
wishes.
|
||
United States
|
1992
|
The mother of an anencephalic baby
wishes to keep the child on life support perpetually.
|
|||
United States
|
2004
|
Parents wish to keep a child on life support.
|
|||
United States
|
2005
|
A family wishes to keep life support for a man in a persistent
vegetative state.
|
|||
United States
|
1984
|
A boy dies at age 12 after living a lifetime with highly
unusual medical care in a sterile environment.
|
|||
United States
|
2013
|
A teenaged woman is declared brain-dead and
her family wishes to maintain her body on mechanical ventilation perpetually.
|
Withholding life-prolonging treatment
|
|||||
case
|
country
|
location
|
year
|
summary
|
|
United States
|
1983
|
The parents of a child born with horrible birth defects
request the right to refuse treatment and keep the child off life support.
|
|||
Australia
|
1989
|
Parents and doctors agreed to withhold life-prolonging
measures of severely disabled newborn baby, including surgeries and
medication, while Right to Life activists claimed the baby was murdered.[40]
|
Informed consent to medical treatment
|
|||||
case
|
country
|
location
|
year
|
summary
|
|
Germany
|
2011
|
Informed consent and involuntary sex reassignment in the case
of an adult intersex woman.
|
|||
England
|
1985
|
The right of minors to request contraception from their doctor
without parental consent.
|
Assisted suicide
|
|||||
case
|
country
|
location
|
year
|
summary
|
|
2007
|
A couple request the legal right to commit suicide together,
although only the husband was ill.
|
||||
United States
|
1973
|
A man who suffered severe burns requests the right to die.
|
|||
Italy
|
2007
|
A man in pain requests a legal right to die.
|
|||
Canada
|
1991
|
A woman requests a right to assisted suicide.
|
|||
Spain
|
1998
|
For 29 years a man requests his right to assisted suicide.
|
|||
India
|
2011
|
A court case debates the right to die for a woman in a
persistent vegetative state for 37 years.
|
|||
Italy
|
2006
|
A patient requests a legal right to die.
|
Euthanasia of another
|
|||||
case
|
country
|
location
|
year
|
summary
|
|
United States
|
2008
|
A parent is charged with critically harming his child who is
on life support. If the child dies, the parent may be charged with murder. At
question was whether parents should be legally allowed to make medical
decisions for children they have allegedly abused.
|
|||
England
|
1993
|
Bland was the first patient in English legal history to be
allowed to die by the courts through the withdrawal of life-prolonging
treatment.
|
|||
United States
|
2002
|
A mother euthanizes her adult sons to relieve their suffering
from Huntington's disease.
|
|||
United States
|
1990
|
The parents of a woman in a persistent vegetative state
request the right to remove her life support equipment.
|
|||
1992
|
Parents receive permission to remove the life support from a
woman in a persistent vegetative state for 17 years.
|
||||
United States
|
2009
|
A sister is charged with euthanizing her brother after he has
medical problems.
|
|||
United States
|
Michigan
|
1994
|
A medical doctor advocates for assisted suicide and
the right
to die.
|
||
Canada
|
1993
|
A man euthanizes his child who has lived for years in pain.
|
|||
United States
|
New Jersey
|
1976
|
A 21-year-old girl is in a persistent vegetative state. Her
parents wish to remove her from artificial respiration.
|
||
United States
|
2005
|
A woman is in a persistent vegetative state. Her husband wishes
to remove her life support. Her parents wish her to remain on life support.
|
|||
United States
|
2013
|
A woman is declared brain-dead by her physician. Her husband
and family wish to remove life support. The hospital persists in keeping her
on life support because it claims it cannot legally withdraw life support
from a pregnant patient.
|
0 Comments:
Post a Comment
<< Home