The 1000th Thread!
| 
Research | |||||
| 
case | 
country | 
location | 
year | 
summary | |
| 
1880s | 
Psychosurgery (also called neurosurgery for mental disorder)
  has a long history. During the 1960s and 1970s, it became the subject of
  increasing public concern and debate, culminating in the US with
  congressional hearings. Particularly controversial was the work of Harvard
  neurosurgeon Vernon Markand psychiatrist Frank Ervin, who wrote a book entitled Violence
  and the Brain in 1970.[1] The National Commission for the
  Protection of Human Subjects of Biomedical and Behavioral Research in 1977
  endorsed the continued limited use of psychosurgical procedures.[1][2]Since then, a few facilities in some
  countries have continued to use psychosurgery on small numbers of patients.
  In the US and other Western countries, the number of operations has further
  declined over the past 30 years, a period during which there have been no
  major advances in ablative psychosurgery.[3] | ||||
| 
United States | 
1920s | 
Controversial psychiatrist Henry Cotton at Trenton State Hospital in New Jersey became
  convinced that insanity was
  fundamentally a toxic disorder and he surgically removed body parts to try to
  improve mental
  health.[4] | |||
| 
United States | 
Iowa | 
1939 | 
The Monster Study is the name given to a stuttering experiment
  performed on orphan children in Davenport, Iowa in
  1939. It was conducted by Wendell Johnson at
  the University
  of Iowa. The research began with the selection of 22 subjects from
  a veterans' orphanage in Iowa. None were told the intent of the research, and
  they believed that they were to receive speech therapy. The study was trying
  to induce stuttering in healthy children. The experiment became national news
  in the San Jose Mercury News in 2001, and a book
  was written. On 17 August 2007, six of the orphan children were awarded
  $925,000 by the State of Iowa for lifelong psychological and emotional scars
  caused by six months of torment during the Iowa University experiment.
  Although none of the children became stutterers, some became self-conscious
  and reluctant to speak.[5] A spokesman for the University of Iowa
  called the experiment "regrettable". | ||
| 
United States | 
Various | 
Occurred over many decades | 
There has been a long history of medical experimentation on African Americans.
  From the era of slavery, when atrocities were committed on black women
  by J.
  Marion Sims, to the present day, Black Americans have been
  unwitting subjects of medical experimentation.[7][8] Author Harriet Washington argues that
  "diverse forms of racial discrimination have shaped both the
  relationship between white physicians and black patients and the attitude of
  the latter towards modern medicine in general".[9] 
In the 1960s, Ionia State Hospital, located in Ionia, Michigan,
  was one of America's largest and most notorious state psychiatric hospitalsin the era before
  deinstitutionalization. Doctors at this hospital diagnosed African Americanswith schizophrenia because
  of their civil
  rightsideas. See The Protest Psychosis. | ||
| 
Plutonium injections | 
United States | 
1945-1947 | 
Eighteen people were
  injected with plutoniumby Manhattan
  Project doctors. None of the patients was told what was going
  on, and the doctors did not ask for their consent. See Eileen Welsome's
  book The Plutonium Files.[10] | ||
| 
United States | 
1946 | 
German medical
  doctors went on criminal trial for Nazi human experimentation. See The Years of Extermination. | |||
| 
U.S./ Guatemala | 
1946-48 | 
The syphilis experiments
  in Guatemala were United
  States human experiments conducted in Guatemala from
  1946 to 1948. The experiments were led by physician John Charles Cutler. They were done during the
  administration of American President Harry S. Truman and
  Guatemalan President Juan
  José Arévalo.[11] 
Doctors infected soldiers, prostitutes, prisoners, and mental patients with syphilisand
  other sexually transmitted diseaseswithout the informed consent of
  the subjects, and treated most subjects with antibiotics. This
  resulted in at least 83 deaths.[12] In October 2010, the US formally
  apologized to Guatemala for conducting these experiments. | |||
| 
United States | 
New York State | 
1950s | 
More than 1200
  homeless men from Lower Manhattan were convinced with promises of food and
  shelter to have their prostates biopsied by a Dr. Perry Hudson. They were not
  informed of possible side effects, i.e., rectal tearing and impotence. The
  homeless were targeted for these biopsies because the biopsies were painful
  and untested, and less vulnerable populations would not volunteer. | ||
| 
Radioactive iodine
  experiments | 
United States | 
1950s | 
The U.S. Atomic Energy Commission has a history of
  involvement in experiments involving radioactive
  iodine. In a 1949 operation called the "Green Run,"
  the AEC released iodine-131and xenon-133 to
  the atmosphere, which contaminated a 500,000-acre (2,000 km2) area containing three small towns near the Hanford site in
  Washington.[13] In 1953, the AEC ran several studies
  on the health effects of radioactive iodine in newborns and pregnant women at
  the University
  of Iowa. Also in 1953, the AEC sponsored a study to discover if
  radioactive iodine affected premature babies
  differently from full-term babies.[14] In another AEC study, researchers at
  the University of Nebraska College of Medicine fed
  iodine-131 to 28 healthy infants through a gastric tube to test the
  concentration of iodine in the infants' thyroid glands.[14] | ||
| 
United States | 
1951 | 
A product derived
  from a cancer patient's specimen, HeLa is the cornerstone of an industry.
  Cancerous tissue was taken from her without her consent. | |||
| 
United States | 
Philadelphia | 
1951-1974 | 
Clinical
  non-therapeutic medical experiments on prison inmates was
  conducted at Holmesburg Prison in Philadelphia from
  1951 to 1974 under the direction of dermatologistAlbert Kligman.[15] | ||
| 
Canada | 
1957–1964 | 
The Allan Memorial Institute is known for its role
  in the Project
  MKULTRA run by the CIA. The Agency's initiative to develop
  drug-induced "mind control" techniques was implemented in the
  institute by its then-Director Donald Ewen Cameron. | |||
| 
UK mental
  institutions | 
UK | 
1960s | 
In the 1960s, there
  was abuse and inhumane treatment of psychiatric patients who were hidden away
  in institutions in the UK. Barbara Robb documented
  her difficult personal experience of being treated at Ely Hospital. She
  wrote the book Sans Everything and she used this to launch a
  campaign to improve or close long stay facilities. Shortly after, a long stay
  hospital for the mentally handicapped in Cardiff was exposed by a nurse
  writing to the News of the World. This exposure prompted an
  official inquiry, which was highly critical of conditions, staff morale, and
  management. At the same time Michael
  Ignatieff and Peter Townsend both published books which
  exposed the poor quality of institutional care.[16] | ||
| 
United States | 
1961 | 
The Milgram
  experiment on obedience to authority figures was a series of notable social
  psychology experiments conducted
  by Yale
  University psychologist Stanley Milgram,
  which measured the willingness of study participants to obey an authority figure who
  instructed them to perform acts that conflicted with their personal conscience.[17] The detailed findings are discussed in
  his 1974 book, Obedience to Authority: An Experimental View.[18] The experiments were controversial,
  and considered by some scientists to be unethical and physically or
  psychologically abusive. Psychologist Diana Baumrind considered
  the experiment "harmful because it may cause permanent psychological damage
  and cause people to be less trusting in the future." [19] | |||
| 
1962-1979 | 
Controversial
  Australian psychiatrist Harry
  Bailey treated mental patients via deep
  sleep therapy and other methods at a Sydney mental hospital.
  He has been linked with the deaths of 85 patients.[20] He committed suicide before he could
  be punished. | ||||
| 
Soviet Union,
  Romania, Hungary, Czechoslovakia, Yugoslavia and China | 
1960s to 1980s | 
Psychiatrists have
  been involved in human rights abuses in states across the world when the
  definitions of mental disease were expanded to include political
  disobedience.[21]:6 In the period from the 1960s to 1986,
  abuse of psychiatry for political purposes was reported to be systematic in
  the Soviet Union and other Eastern European countries.[22]:66 Political abuse of psychiatry also
  takes place in the People's Republic of China.[23] Psychiatric diagnoses such as the
  diagnosis of "sluggish schizophrenia" in political
  dissidents in the USSR were used for political purposes.[24]:77 | |||
| 
United States | 
1971 | 
The Stanford prison
  experiment was a study of the psychological effects
  of becoming a prisoner or prison guard. The
  experiment was conducted in August 1971 by a team of researchers led by
  psychology professor Philip Zimbardo.[25] Participants took on the roles of
  prisoners and guards in a mock prison situated
  in the basement of the Stanford psychology building. Some of the prisoners
  were subjected to psychological torture. Many of the prisoners
  passively accepted psychological abuse, and Zimbardo himself permitted the
  abuse to continue. Two of the prisoners quit the experiment early and the
  entire experiment was abruptly stopped after only six days. Certain portions
  of the experiment were filmed and excerpts of footage are publicly available. | |||
| 
United States | 
1970s | 
Human radiation
  experiments were directed by the United States Atomic Energy Commissionand
  the Manhattan Project. In Nashville, pregnant women were given radioactive
  mixtures. In Cincinnati, some 200 patients were irradiated over a period of
  15 years. In Chicago, 102 people received injections of strontium and cesium
  solutions. In Massachusetts, 74 schoolboys were fed oatmeal that contained
  radioactive substances. In all of these cases, the subjects did not know what
  was going on and did not give informed consent.[10] The government covered up most of
  these radiation mishaps until 1993, when President Bill Clinton ordered
  a change of policy. The resulting investigation was undertaken by the Advisory Committee on Human
  Radiation Experiments. See The Plutonium Files. | |||
| 
United States | 
1972 | 
A 40-year experiment
  conducted by the U.S. Public Health Service withheld standard medical advice
  and treatment from a poor minority population with an easily treatable
  disease. The experiment targeted black male farmers who were told they needed
  to be treated for 'bad blood',[26] some of whom had previously
  encountered syphilis. Others were intentionally given syphilis during the
  course of the experiment. In addition to many fatalities, some children were
  born with congenital syphilis due to the study. | |||
| 
United States | 
1976 | 
Researchers
  commercialized a patient's discarded body parts. The man did not authorize
  the use of his bodily tissues or fluids, and researchers did not obtain
  informed consent. He did not want his donation to generate commercial profit
  for private entities. | |||
| 
1980s | 
Eugene Ellsworth
  Landy was an American psychologist and psychotherapist best known for his
  unconventional 24-hour therapy as well as ethical violations concerning his
  treatment of Beach
  Boys co-founder Brian Wilson in
  the 1980s. In 2015, Landy's relationship with Wilson was dramatized in
  the biographical
  filmLove & Mercy. | ||||
| 
United States | 
1987 | 
A school had been
  infecting disabled children in experiments for years. | |||
| 
Canada, United
  States | 
12 psychiatric
  centers | 
1994–2001 | 
SmithKlineBeecham,
  known since 2000 as GlaxoSmithKline,
  conducted a clinical trial from 1994 to 1997 in 12 pychiatric centers in
  North America to study the efficacy of paroxetine(Paxil,
  Seroxat), an anti-depressant, on teenagers. The trial data suggested that the
  drug was not efficacious and that the paroxetine group were more likely to
  think about suicide. The paper that wrote up the study was published in 2001,
  osensibly authored by a group of academics, but actually ghostwritten by the
  drug company. The article downplayed the negative findings and concluded that
  paroxetine helped with teenage depression. The company used this paper to
  promote paroxetine for teenagers. The ensuing controversy led to several
  lawsuits, including from the parents of teenagers who killed themselves while
  taking the drug, and intensified the debate about medical ghostwriting and conflict of interest in clinical trials. In
  2012 the US Justice Department fined GlaxoSmithKline $3 billion for several
  violations, including withholding data on paroxetine, unlawfully promoting it
  for adolescents, and preparing a misleading article about study 329. New
  Scientist wrote in 2015: "You may never have heard of it, but
  Study 329 changed medicine."[27] | ||
| 
Death associated
  with psychotropic drugs | 
United States | 
1998 | 
In 1998,
  60-year-old Donald Schell went to see his doctor
  complaining of difficulty sleeping. He was diagnosed with an anxiety state
  and placed on Paxil, an SSRI anti-depressant. Within 48 hours
  of being put on Paxil Schell killed his wife, daughter, infant granddaughter,
  and himself. Tim Tobin, Schell’s son-in-law, took legal action against
  SmithKline (now GlaxoSmithKline).
  The Tobin case was heard in Wyoming from
  May 21 to June 6, 2001. The jury returned a guilty verdict against SmithKline
  and awarded Tobin $6.4 million.[28][29][30][31]This was the first guilty verdict returned
  against a pharmaceutical company
  regarding adverse behavioral effects of a psychotropic drug.[28] | ||
| 
United States | 
2002 | 
Courtney is a
  former pharmacist who
  owned and operated Research Medical Tower Pharmacy in Missouri.[32] In 2002, he was convicted of
  pharmaceutical fraud and sentenced to federal prison.[32] | |||
| 
United States | 
2003 | 
Patients donated
  tissue samples, which researchers subsequently used in a plan to generate
  profit. | |||
| 
GlaxoSmithKlinehuman
  experiments | 
Various | 
2004–2012 | 
In 2004 GlaxoSmithKline (GSK)
  sponsored at least four medical trials using Hispanic and black children
  at New
  York's Incarnation Children's Center. Normally trials on
  children require parental consent but, as the infants were in care, New
  York's authorities held that role. Experiments were designed to test the
  “safety and tolerance” of AIDS medications,
  some of which have potentially dangerous side effects.[33] 
In 2006, GSK and the US Army were criticized for Hepatitis E vaccine experiments
  conducted in 2003 on 2,000 soldiers of the Royal Nepalese Army. It was said that using
  soldiers as volunteers is unethical because they "could easily be
  coerced into taking part."[34] 
In January 2012, GSK and two scientists who led the trials
  were fined approximately $240,000 in Argentina for "experimenting with
  human beings" and "falsifying parental authorization" during
  vaccine trials on 15,000 children under the age of one. Babies were recruited
  from poor families that visited public hospitals for medical treatment.
  Fourteen babies allegedly died as a result of the trials.[35] | ||
| 
Death from
  prescription drugs | 
United States | 
2006 | 
Rebecca Riley, the
  daughter of Michael and Carolyn Riley of Massachusetts, was found dead in her
  home at age four, her lungs filled with fluid, after prolonged exposure to
  various medications. The medical examiner's office determined the girl died
  from "intoxication due to the combined effects" of prescription
  drugs. Police reports state she was taking 750 milligrams a day of Depakote, 200
  milligrams a day of Seroquel,
  and .35 milligrams a day of Clonidine. Rebecca had been taking the drugs
  since the age of two for bipolar disorder and ADHD, diagnosed by child psychiatrist Kayoko
  Kifuji of the Tufts-New England Medical Center.[36] | ||
| 
University of MinnesotaResearch Participant Dan
  Markingson | 
United States | 
Minnesota | 
2004 | 
University of Minnesota research participant Dan Markingson committed
  suicide in May 2004 while enrolled in an industry-sponsored pharmaceutical
  trial comparing three FDA-approved atypical antipsychotics: Seroquel (quetiapine), Zyprexa (olanzapine),
  and Risperdal
  (risperidone). Writing on the circumstances surrounding
  Markingson's death in the study, which was designed and funded by Seroquel
  manufacturer AstraZeneca,
  University of Minnesota Professor of Bioethics Carl Elliott noted that Markingson was
  enrolled in the study against the wishes of his mother, Mary Weiss, and that
  he was forced to choose between enrolling in the study or being involuntarily
  committed to a state mental institution.[37] Further investigation revealed financial
  ties to AstraZeneca by Markingson's psychiatrist, Dr. Stephen C. Olson,
  oversights and biases in AstraZeneca's trial design, and the inadequacy of
  university Institutional Review Board (IRB)protections for
  research subjects.[38] Although a 2005 FDA investigation
  appeared to clear the university, greater awareness of the case stemming from
  Elliott's 2010 article in the magazine Mother Jones resulted in a group of
  university faculty members sending a public letter to the Board of Regents
  urging an external investigation into Markingson's death.[39] | |
| 
case | 
country | 
location | 
year | 
summary | |
| 
United States | 
2008 | 
A hospital wished to withhold treatment from someone whom it
  judges to have no chance of living. | |||
| 
United States | 
2008 | 
The parents of a brain-dead boy wanted to keep him on life
  support. | |||
| 
United States | 
2007 | 
Prison officials question whether to force-feed inmates who
  are on hunger strike. | |||
| 
United Kingdom | 
2017 | 
After losing a UK Supreme Court case, the parents of Gard, 10
  months, petitioned the EU Court in France, and lost the final appeal. They
  wanted the hospital to allow them to travel to the U.S. for an experimental
  therapy that may have provided some temporary benefit but likely would not have
  improved his neurological condition, due to a mitochondrial
  DNA depletion disease (the treatment is nucleoside bypass therapy). At the least, they
  wanted for the hospital to continue to provide advanced life support palliative care for
  their son—respiration, nutrition, hydration—or to send him home on life
  support to eventually die, but those requests were also denied and support
  will be turned off. | |||
| 
United States | 
2005 | 
The hospital removes life support from an unconscious immigrant
  from Eritrea against
  her family's wishes. The family are in a foreign country and unable to
  travel. | |||
| 
2010 | 
A man seems to be in a persistent vegetative state, and after
  23 years a communication test is conducted. | ||||
| 
United States | 
Texas | 
2004 | 
An infant is removed from life support against his mother's
  wishes. | ||
| 
United States | 
1992 | 
The mother of an anencephalic baby
  wishes to keep the child on life support perpetually. | |||
| 
United States | 
2004 | 
Parents wish to keep a child on life support. | |||
| 
United States | 
2005 | 
A family wishes to keep life support for a man in a persistent
  vegetative state. | |||
| 
United States | 
1984 | 
A boy dies at age 12 after living a lifetime with highly
  unusual medical care in a sterile environment. | |||
| 
United States | 
2013 | 
A teenaged woman is declared brain-dead and
  her family wishes to maintain her body on mechanical ventilation perpetually. | |||
| 
Withholding life-prolonging treatment | |||||
| 
case | 
country | 
location | 
year | 
summary | |
| 
United States | 
1983 | 
The parents of a child born with horrible birth defects
  request the right to refuse treatment and keep the child off life support. | |||
| 
Australia | 
1989 | 
Parents and doctors agreed to withhold life-prolonging
  measures of severely disabled newborn baby, including surgeries and
  medication, while Right to Life activists claimed the baby was murdered.[40] | |||
| 
Informed consent to medical treatment | |||||
| 
case | 
country | 
location | 
year | 
summary | |
| 
Germany | 
2011 | 
Informed consent and involuntary sex reassignment in the case
  of an adult intersex woman. | |||
| 
England | 
1985 | 
The right of minors to request contraception from their doctor
  without parental consent. | |||
| 
Assisted suicide | |||||
| 
case | 
country | 
location | 
year | 
summary | |
| 
2007 | 
A couple request the legal right to commit suicide together,
  although only the husband was ill. | ||||
| 
United States | 
1973 | 
A man who suffered severe burns requests the right to die. | |||
| 
Italy | 
2007 | 
A man in pain requests a legal right to die. | |||
| 
Canada | 
1991 | 
A woman requests a right to assisted suicide. | |||
| 
Spain | 
1998 | 
For 29 years a man requests his right to assisted suicide. | |||
| 
India | 
2011 | 
A court case debates the right to die for a woman in a
  persistent vegetative state for 37 years. | |||
| 
Italy | 
2006 | 
A patient requests a legal right to die. | |||
| 
Euthanasia of another | |||||
| 
case | 
country | 
location | 
year | 
summary | |
| 
United States | 
2008 | 
A parent is charged with critically harming his child who is
  on life support. If the child dies, the parent may be charged with murder. At
  question was whether parents should be legally allowed to make medical
  decisions for children they have allegedly abused. | |||
| 
England | 
1993 | 
Bland was the first patient in English legal history to be
  allowed to die by the courts through the withdrawal of life-prolonging
  treatment. | |||
| 
United States | 
2002 | 
A mother euthanizes her adult sons to relieve their suffering
  from Huntington's disease. | |||
| 
United States | 
1990 | 
The parents of a woman in a persistent vegetative state
  request the right to remove her life support equipment. | |||
| 
1992 | 
Parents receive permission to remove the life support from a
  woman in a persistent vegetative state for 17 years. | ||||
| 
United States | 
2009 | 
A sister is charged with euthanizing her brother after he has
  medical problems. | |||
| 
United States | 
Michigan | 
1994 | 
A medical doctor advocates for assisted suicide and
  the right
  to die. | ||
| 
Canada | 
1993 | 
A man euthanizes his child who has lived for years in pain. | |||
| 
United States | 
New Jersey | 
1976 | 
A 21-year-old girl is in a persistent vegetative state. Her
  parents wish to remove her from artificial respiration. | ||
| 
United States | 
2005 | 
A woman is in a persistent vegetative state. Her husband wishes
  to remove her life support. Her parents wish her to remain on life support. | |||
| 
United States | 
2013 | 
A woman is declared brain-dead by her physician. Her husband
  and family wish to remove life support. The hospital persists in keeping her
  on life support because it claims it cannot legally withdraw life support
  from a pregnant patient. | |||
 . PMID 19797603.
. PMID 19797603. . PMID 19892821.
. PMID 19892821.



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